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	<title>Comments on: Another Tiny, Exciting Step Toward Life-Extension</title>
	<atom:link href="http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/feed/" rel="self" type="application/rss+xml" />
	<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/</link>
	<description>The science of futurist technologies—and an excuse to soak in sci-fi TV shows, books, movies, toys, and video games.</description>
	<lastBuildDate>Wed, 22 Feb 2012 16:57:08 +0000</lastBuildDate>
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		<title>By: Mark</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-32113</link>
		<dc:creator>Mark</dc:creator>
		<pubDate>Mon, 08 Aug 2011 18:22:39 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-32113</guid>
		<description>22 Years human immortality is coming.</description>
		<content:encoded><![CDATA[<p>22 Years human immortality is coming.</p>
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		<title>By: Greg</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-32095</link>
		<dc:creator>Greg</dc:creator>
		<pubDate>Sun, 07 Aug 2011 15:10:24 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-32095</guid>
		<description>All they really showed was that if you trash the normal levels of telomerase, mice appear to age faster, and restoring telomerase overcomes the problems of not expressing enough telomerase.   

Seems to me there are probably many genes that you could mess up that would achieve similar effects.  Take insulin, for example.  If mice had decreased capacity to express insulin, they would appear to age more rapidly as ravages of uncontrolled blood sugar wreaks havoc.  With insulin restored, they&#039;d stop their rapid decline (though much of the damage is irreversible).  

This study says nothing whatsoever about extending lifespan in anything.  It merely describes treating induced telomerase deficiency by supplying necessary levels of telomerase.</description>
		<content:encoded><![CDATA[<p>All they really showed was that if you trash the normal levels of telomerase, mice appear to age faster, and restoring telomerase overcomes the problems of not expressing enough telomerase.   </p>
<p>Seems to me there are probably many genes that you could mess up that would achieve similar effects.  Take insulin, for example.  If mice had decreased capacity to express insulin, they would appear to age more rapidly as ravages of uncontrolled blood sugar wreaks havoc.  With insulin restored, they&#8217;d stop their rapid decline (though much of the damage is irreversible).  </p>
<p>This study says nothing whatsoever about extending lifespan in anything.  It merely describes treating induced telomerase deficiency by supplying necessary levels of telomerase.</p>
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		<title>By: Another Tiny, Exciting Step Toward Life-Extension &#124; Science Not Fiction</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-32085</link>
		<dc:creator>Another Tiny, Exciting Step Toward Life-Extension &#124; Science Not Fiction</dc:creator>
		<pubDate>Sun, 07 Aug 2011 02:48:08 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-32085</guid>
		<description>[...]  &#098;&#121; Kyle Munkittrick &#105;&#110; Aging (&amp;#959r N&amp;#959t), Biology &#124; 14 observations &#124; RSS feed &#124; Trackback     hopfeed_template=&#039;&#039;; hopfeed_align=&#039;CENTER&#039;; hopfeed_type=&#039;IFRAME&#039;; [...]</description>
		<content:encoded><![CDATA[<p>[...]  &#098;&#121; Kyle Munkittrick &#105;&#110; Aging (&amp;#959r N&amp;#959t), Biology | 14 observations | RSS feed | Trackback     hopfeed_template=&#039;&#039;; hopfeed_align=&#039;CENTER&#039;; hopfeed_type=&#039;IFRAME&#039;; [...]</p>
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		<title>By: Reverse Aging</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-27181</link>
		<dc:creator>Reverse Aging</dc:creator>
		<pubDate>Tue, 18 Jan 2011 05:15:11 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-27181</guid>
		<description>Caloric restriction looks like it is able to extend life in rats by up to 2 times. Looks like scientists are going to try with non-human primates first, then move into human trials. So far the results seem promising.</description>
		<content:encoded><![CDATA[<p>Caloric restriction looks like it is able to extend life in rats by up to 2 times. Looks like scientists are going to try with non-human primates first, then move into human trials. So far the results seem promising.</p>
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		<title>By: Enjoy a Longer Lifespan with Science and Work &#124; Minitrends</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-26093</link>
		<dc:creator>Enjoy a Longer Lifespan with Science and Work &#124; Minitrends</dc:creator>
		<pubDate>Fri, 10 Dec 2010 10:06:07 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-26093</guid>
		<description>[...] it did not extend the lives of the mice one bit; it merely returned them to a normal longevity. Kyle Munkittrick at Discover is also skeptical of the translation of this breakthrough to humans: It still remains to be seen if telomerase [...]</description>
		<content:encoded><![CDATA[<p>[...] it did not extend the lives of the mice one bit; it merely returned them to a normal longevity. Kyle Munkittrick at Discover is also skeptical of the translation of this breakthrough to humans: It still remains to be seen if telomerase [...]</p>
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		<title>By: Al Feersum</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-26017</link>
		<dc:creator>Al Feersum</dc:creator>
		<pubDate>Thu, 09 Dec 2010 11:13:07 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-26017</guid>
		<description>Baby steps... even if telomer manipulation &lt;i&gt;doesn&#039;t&lt;/i&gt; stop death by aging, but could &lt;i&gt;slightly&lt;/i&gt; delay it, it&#039;s a step forward.  If we could delay senescence by, say, 10 years, or even 20, it might just give us enough time to make the next baby step forward, and bolt on another 10 or 20 years, which, in turn, may allow us to take the &lt;i&gt;next&lt;/i&gt; and so on.

I firmly believe that there are people alive today that will live 150 years.  I&#039;d like one of those people to be me.  Maybe when I&#039;m 150, there might be another extension treatment.  Or even the option of &#039;life data&#039; storage, for when I can get a new, younger, body, vat grown to my specification.  The ideas are there, and have been for many years.  We just need technology to catch up.  Unfortunately, in order for technology to &lt;i&gt;really&lt;/i&gt; progress, and quickly, we need lots of wars*, otherwise progress tends to stagnate.

* We have made some of our most significant scientific breakthroughs that have peacetime applications as a result of the arms race.</description>
		<content:encoded><![CDATA[<p>Baby steps&#8230; even if telomer manipulation <i>doesn&#8217;t</i> stop death by aging, but could <i>slightly</i> delay it, it&#8217;s a step forward.  If we could delay senescence by, say, 10 years, or even 20, it might just give us enough time to make the next baby step forward, and bolt on another 10 or 20 years, which, in turn, may allow us to take the <i>next</i> and so on.</p>
<p>I firmly believe that there are people alive today that will live 150 years.  I&#8217;d like one of those people to be me.  Maybe when I&#8217;m 150, there might be another extension treatment.  Or even the option of &#8216;life data&#8217; storage, for when I can get a new, younger, body, vat grown to my specification.  The ideas are there, and have been for many years.  We just need technology to catch up.  Unfortunately, in order for technology to <i>really</i> progress, and quickly, we need lots of wars*, otherwise progress tends to stagnate.</p>
<p>* We have made some of our most significant scientific breakthroughs that have peacetime applications as a result of the arms race.</p>
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		<title>By: Kyle Munkittrick</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25722</link>
		<dc:creator>Kyle Munkittrick</dc:creator>
		<pubDate>Mon, 06 Dec 2010 00:19:09 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25722</guid>
		<description>@Brian Too: Zoidberg isn&#039;t actually an alien. He&#039;s what became of humanity after the lobster longevity disaster.

@Jeffery: I imagine simple logistics. They wanted to see what happened when normal levels were restored first. Now on to all the various permutations and other tests. Science never sleeps!

@Durr Hurr: Now, reggie didn&#039;t identify himself as a voluntary human extinction type fellow, but the snark was warranted. I&#039;ll allow it!</description>
		<content:encoded><![CDATA[<p>@Brian Too: Zoidberg isn&#8217;t actually an alien. He&#8217;s what became of humanity after the lobster longevity disaster.</p>
<p>@Jeffery: I imagine simple logistics. They wanted to see what happened when normal levels were restored first. Now on to all the various permutations and other tests. Science never sleeps!</p>
<p>@Durr Hurr: Now, reggie didn&#8217;t identify himself as a voluntary human extinction type fellow, but the snark was warranted. I&#8217;ll allow it!</p>
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		<title>By: Durr Hurr</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25721</link>
		<dc:creator>Durr Hurr</dc:creator>
		<pubDate>Sun, 05 Dec 2010 23:54:04 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25721</guid>
		<description>Reggie: Please set a good example for the rest of us and help out our poor ailing Earth by killing yourself as soon as possible.</description>
		<content:encoded><![CDATA[<p>Reggie: Please set a good example for the rest of us and help out our poor ailing Earth by killing yourself as soon as possible.</p>
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		<title>By: Jeffrey</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25715</link>
		<dc:creator>Jeffrey</dc:creator>
		<pubDate>Sun, 05 Dec 2010 22:48:49 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25715</guid>
		<description>Is there any reason why this study didn&#039;t concurrently try &quot;telomerase manipulation treatment&quot; on naturally aged mice as well?</description>
		<content:encoded><![CDATA[<p>Is there any reason why this study didn&#8217;t concurrently try &#8220;telomerase manipulation treatment&#8221; on naturally aged mice as well?</p>
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		<title>By: reggie</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25697</link>
		<dc:creator>reggie</dc:creator>
		<pubDate>Sun, 05 Dec 2010 12:20:25 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25697</guid>
		<description>There&#039;s nothing &quot;exciting&quot; about the prospect of increasing human longevity... anymore than global warming is &quot;exciting&quot; (...it&#039;s scary!). There are so many more important ways to spend precious research $$$ than increasing the time on Earth of the planet&#039;s most destructive species. Fear of aging = a selfish waste of time and resources.</description>
		<content:encoded><![CDATA[<p>There&#8217;s nothing &#8220;exciting&#8221; about the prospect of increasing human longevity&#8230; anymore than global warming is &#8220;exciting&#8221; (&#8230;it&#8217;s scary!). There are so many more important ways to spend precious research $$$ than increasing the time on Earth of the planet&#8217;s most destructive species. Fear of aging = a selfish waste of time and resources.</p>
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		<title>By: Brian Too</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25618</link>
		<dc:creator>Brian Too</dc:creator>
		<pubDate>Sat, 04 Dec 2010 01:27:02 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25618</guid>
		<description>Up next, lobster/human gene therapy!  A lobster in every pot!  Strange extracts of lobster that cost a fortune and have an army of shills, er, true believers, to market the goods!

Reputable scientists pooh-pooh the magical, miracle lobster anti-aging remedies!  What are they hiding*?!


* Lobster therapy may exhibit side effects such as sweating, convulsions, diarrea, constipation, premature aging, reverse aging, insomnia, excessive sleeping, reddened skin, thickened fingernails, carapice formation, antenna growth, and lobster hands.</description>
		<content:encoded><![CDATA[<p>Up next, lobster/human gene therapy!  A lobster in every pot!  Strange extracts of lobster that cost a fortune and have an army of shills, er, true believers, to market the goods!</p>
<p>Reputable scientists pooh-pooh the magical, miracle lobster anti-aging remedies!  What are they hiding*?!</p>
<p>* Lobster therapy may exhibit side effects such as sweating, convulsions, diarrea, constipation, premature aging, reverse aging, insomnia, excessive sleeping, reddened skin, thickened fingernails, carapice formation, antenna growth, and lobster hands.</p>
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		<title>By: captainhurt</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25608</link>
		<dc:creator>captainhurt</dc:creator>
		<pubDate>Fri, 03 Dec 2010 18:29:12 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25608</guid>
		<description>bla bla bla ... show us the trillion dollar focused, committed effort to DO something for the masses...not just talk about little lab experiments.</description>
		<content:encoded><![CDATA[<p>bla bla bla &#8230; show us the trillion dollar focused, committed effort to DO something for the masses&#8230;not just talk about little lab experiments.</p>
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		<title>By: News about Anti-Aging issue #1 &#124; Free Information on Anti-Aging and Health as We Grow Older</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25582</link>
		<dc:creator>News about Anti-Aging issue #1 &#124; Free Information on Anti-Aging and Health as We Grow Older</dc:creator>
		<pubDate>Fri, 03 Dec 2010 08:07:25 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25582</guid>
		<description>[...] at least five, and I suspect her &quot;anti-aging&quot; style and beauty tricks ma  more&#8230;    Another Tiny, Exciting Step Toward Life-Extension &#8211; Discover Magazine (blog) &#8211; blogs.discovermagazine.com 12/02/2010 Discover Magazine (blog)Another Tiny, Exciting Step [...]</description>
		<content:encoded><![CDATA[<p>[...] at least five, and I suspect her &quot;anti-aging&quot; style and beauty tricks ma  more&#8230;    Another Tiny, Exciting Step Toward Life-Extension &#8211; Discover Magazine (blog) &#8211; blogs.discovermagazine.com 12/02/2010 Discover Magazine (blog)Another Tiny, Exciting Step [...]</p>
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		<title>By: Antiaging4life</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25568</link>
		<dc:creator>Antiaging4life</dc:creator>
		<pubDate>Fri, 03 Dec 2010 00:04:19 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25568</guid>
		<description>The discovery of telomeres and telomerase gene activation won the 2009 Nobel prize in medicine or physiology. TA-65 is the only proven and patented telomerase gene activating substance on the market to date, but like all new discoveries, is too expensive for the masses at this early stage.

The price has come down from $25,000 per year to $8,000 per year. With new breakthroughs in production and possible new sources (currently the Chinese herb Astragalus), the costs will come down. You can’t just take Astragalus for these benefits as it takes incredible amounts of the raw herb to produce minute amounts of the extracted molecule that provides the life extension benefits.</description>
		<content:encoded><![CDATA[<p>The discovery of telomeres and telomerase gene activation won the 2009 Nobel prize in medicine or physiology. TA-65 is the only proven and patented telomerase gene activating substance on the market to date, but like all new discoveries, is too expensive for the masses at this early stage.</p>
<p>The price has come down from $25,000 per year to $8,000 per year. With new breakthroughs in production and possible new sources (currently the Chinese herb Astragalus), the costs will come down. You can’t just take Astragalus for these benefits as it takes incredible amounts of the raw herb to produce minute amounts of the extracted molecule that provides the life extension benefits.</p>
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		<title>By: Andrew Straw</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25556</link>
		<dc:creator>Andrew Straw</dc:creator>
		<pubDate>Thu, 02 Dec 2010 20:46:00 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25556</guid>
		<description>Cold water?  That&#039;s a natural reaction, but, as I like to say...

Everything&#039;s a fad...until it isn&#039;t.

And regarding the telomerase in mice versus humans, mice appear to use telomerase throughout their lives, while humans don&#039;t except in the gametes and a few other cell types.
On the other hand, telomerase is what lets an embryo divide so many times (well beyond the Hayflick limit) without every embryo dying or getting cancer.  That fact is what is exciting to me.</description>
		<content:encoded><![CDATA[<p>Cold water?  That&#8217;s a natural reaction, but, as I like to say&#8230;</p>
<p>Everything&#8217;s a fad&#8230;until it isn&#8217;t.</p>
<p>And regarding the telomerase in mice versus humans, mice appear to use telomerase throughout their lives, while humans don&#8217;t except in the gametes and a few other cell types.<br />
On the other hand, telomerase is what lets an embryo divide so many times (well beyond the Hayflick limit) without every embryo dying or getting cancer.  That fact is what is exciting to me.</p>
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		<title>By: News about Anti Aging issue #8</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25544</link>
		<dc:creator>News about Anti Aging issue #8</dc:creator>
		<pubDate>Thu, 02 Dec 2010 17:57:43 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25544</guid>
		<description>[...] 2nd, 2010 &#124; Posted by wlben &#124; Category: anti-aging &#124; Tags: anti-aging &#124; No Comments    Another Tiny, Exciting Step Toward Life-Extension &#8211; Discover Magazine (blog) &#8211; blogs.discovermagazine.com 12/02/2010 Discover Magazine (blog)Another Tiny, Exciting Step [...]</description>
		<content:encoded><![CDATA[<p>[...] 2nd, 2010 | Posted by wlben | Category: anti-aging | Tags: anti-aging | No Comments    Another Tiny, Exciting Step Toward Life-Extension &#8211; Discover Magazine (blog) &#8211; blogs.discovermagazine.com 12/02/2010 Discover Magazine (blog)Another Tiny, Exciting Step [...]</p>
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		<title>By: Bigby</title>
		<link>http://blogs.discovermagazine.com/sciencenotfiction/2010/12/02/another-tiny-exciting-step-toward-life-extension/comment-page-1/#comment-25534</link>
		<dc:creator>Bigby</dc:creator>
		<pubDate>Thu, 02 Dec 2010 15:32:41 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/sciencenotfiction/?p=3405#comment-25534</guid>
		<description>You mean...Santa Claus isn&#039;t real?</description>
		<content:encoded><![CDATA[<p>You mean&#8230;Santa Claus isn&#8217;t real?</p>
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