The engineered ovary after 48 hours.
For many cancer patients, treatment can be a double-edged sword. While recent advances in chemotherapy, radiation therapy, and surgery have brought relief to millions of sufferers, a significant fraction have had to sacrifice their ability to have children in return. Going under the knife or being bombarded by high-energy rays—though often critical for therapy—can sometimes irreparably damage a woman’s eggs or man’s testes, robbing them of their fertility. To say that this leaves young patients pondering therapy with an unenviable set of choices would be something of an understatement.
Fortunately, thanks to some groundbreaking work by researchers from Brown University, female patients may soon never have to make this most difficult of decisions. A team led by Sandra Carson, a professor of obstetrics and gynecology, has built the first synthetic human ovary from scratch by cobbling together the three cell lines involved in egg development—the theca cells, granulosa cells, and egg cells themselves—into a fully three-dimensional honeycomb-shaped structure.
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As part of DISCOVER’s 30th anniversary celebration, the magazine invited 11 eminent scientists to look forward and share their predictions and hopes for the next three decades. But we also want to turn this over to Science Not Fiction’s readers: How do you think science will improve the world by 2040?
Below are short excerpts of the guest scientists’ responses, with links to the full versions:
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If the oceans eventually become too acidified to sustain most marine life and the jellyfish take over, we can at least take solace in the fact that we’ll have an abundant source of renewable energy. GFP (Green Fluorescent Protein), the same protein isolated in Aequorea victoria that earned three researchers the Nobel Prize in chemistry in 2008, has found a new lease of life in solar and fuel cells being developed by Zackary Chiragwandi at the Chalmers University of Technology in Sweden. Much like the dye found in cutting-edge dye-sensitized solar cells, GFP absorbs a specific wavelength of sunlight—in this case, ultraviolet light—to excite electrons that are shuttled off to an aluminum electrode to generate a current. After giving up their energy, the electrons are then returned to the GFP molecules, where they are ready for another round of stimulation (so to speak).
The cell’s design is simple: two aluminum electrodes are placed onto a thin layer of silicon dioxide, which helps to optimize light capture and energy conversion efficiency, and a single drop of GFP is deposited between them. Without prodding, the protein then self-assembles into strands to connect the electrodes and form a tiny circuit. While cheaper than conventional solar cells, dye-sensitized cells still require some costly materials and are hard to build, making these bio-inspired cells potentially a much more alluring proposition down the line. And because slightly different versions of GFP are found in a number of other marine species, there is the potential for an entire array of more finely tuned GFP cells. (more…)
When William McDonough and other pioneers of the sustainable architecture movement first envisioned the concept of living, breathing buildings, it’s safe to say that they probably didn’t have structures teeming with actual living, breathing bacteria in mind. But don’t tell that to Henk Jonkers of Delft University of Technology in the Netherlands. What he and his colleagues have developed—a self-fixing bacteria-concrete hybrid—may do more to propel sustainable architecture into the mainstream than McDonough could have ever hoped for.
While it may sound unheard of, scientists have been pressing bacteria into service in construction for years. The use of mineral-producing bacteria has already been explored in a variety of applications, including the hardening of sand and in repairing cracks in concrete. But there are two problems inherent to this approach. First, the reaction that these bacteria undergo to synthesize calcium carbonate results in the production of ammonium, which is toxic at even moderate concentrations. The other problem is a more prosaic one. Since the bacteria have to be applied manually, a worker or team of workers would have to go out every few weeks to patch up every little crack on every slab of concrete—nearly defeating the purpose of making the repair process simpler and more cost-effective.
Jonkers’ solution was to track down a different bacterial strain that could live happily buried in the concrete for prolonged periods of time. Because the bacteria would be mixed into the concrete from the start, they could immediately nip small cracks in the bud before they had a chance to expand and become exposed to water, rendering them vulnerable to further wear and tear. (Concrete structures are typically reinforced with steel bars, but these can easily become corroded when water seeps into the cracks.) Such a strain would have to endure the high pH environment of concrete and churn out copious amounts of calcium carbonate without also producing large quantities of ammonium. (more…)
Researchers’ new-found interest in frogs may only be skin-deep, but that’s not necessarily a bad thing. Because hidden within their rugose (science-ese for “wrinkled”) flesh may lie a bumper crop of powerful antibiotics. Though hardly a secret among researchers, who’ve been singing their praises as a potential treasure trove for new drugs for years, efforts to systematically catalog—or even investigate—the thousands of amphibians that could yield promising new antimicrobial substances have been few and far between.
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In a few years’ time, recharging your handheld PC may be as easy as just slipping it into your back pocket. That is, as long as you don’t mind having a virus cocktail woven into your pair of slacks. Yes, the humble virus–that tiny protein-coated bag of genetic material that we more commonly associate with global pandemics–could replace graphite and lithium iron phosphate as the material of choice with which to build the next generation of customizable, high-powered, lithium-ion batteries.
Despite what you may think, this isn’t actually such an unusual pairing. By virtue of their simple design (most only contain enough genes to encode a few dozen proteins) and infinite capacity for manipulation, viruses have become the favored go-to tool for scientists seeking to explore cellular systems and tinker with their underlying components. Gene therapists have been infecting bacterial, plant, and animal cells with viruses for years in order to shuttle in new genes and repair malfunctioning ones. In one recent application, a team of researchers led by University of Pennsylvania ophthalmologist Arthur Cideciyan restored sight to two blind individuals by injecting a virus equipped with a retinal gene into their eyes. (more…)
Having already become a ubiquitous part of our mobile-centric daily lives, wireless technologies are now poised to slip inside our bodies. Researchers and companies around the world are designing the next generation of biosensors—implantable microchip-like devices that can monitor a patient’s health and ping doctors on their smartphones or computers if something is amiss. One day, some of these devices could even apply short-term fixes or treat disorders outright.
The major challenge that scientists face is developing a sensor that is both long-lived and biocompatible. The human body is extremely picky about implants, and will quickly reject or react poorly to most materials found in everyday electronics. Even the materials that make peace with the body’s immune system, like those found in pacemakers, are not always ideal. Some require constant maintenance, while others need to be replaced every few days and are inconvenient to install, to say the least.
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The neurons of a patient suffering from Alzheimer’s.
You may not be consciously aware of it, but at any given time your brain is playing host to billions of simultaneous conversations (and no, I’m not talking about those voices). I speak, of course, of the conversations between your neurons—the incessant neural jabbering that makes it possible for you to move your limbs, learn, remember, and feel pain. Every time we experience a new sensation or form a memory, millions of electrical and chemical signals are propagated across dense networks of axons and jump from one synapse to the next, building new neuronal connections or strengthening existing ones. And they are constantly changing—forming and reforming associations with other neurons in response to how the brain perceives and processes new bits of information.
Despite being central to our understanding of how the brain functions, these neural chats remain largely a mystery to scientists. What exactly are the individual neurons “saying” to each other? And how do these electrical and chemical “messages” become translated into actions, memories, or a range of other complex behaviors? To help decipher these discussions, a team of researchers from the University of Calgary led by bioengineer Naweed Syed have built a silicon microchip embedded with large networks of brain cells. The idea is to get the brain cells to “talk” to the millimeter-square chip—and then have the chip talk to the scientists through a computer interface.
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Tattoos are a nerd’s best friend. The Loom’s science tattoo emporium is all the proof I need. But Frog Design‘s idea for Dattoos takes things to the next level:
The concept of the Dattoo arose in response to current trends towards increasing connectivity and technology as self-expression. To realize a state of constant, seamless connectivity and computability required the convergence of technology and self. The body would need to literally become the interface. Computers and communication devices require physical space, surfaces, and energy. The idea of DNA tattoos (Dattoos) is to use the body itself as hardware and interaction platform, through the use of minimally-invasive, recyclable materials.
The picture reminds me of the Buzz Lightyear/ Turanga Leela style forearm computer. That seems like a pretty practical place to put a Dattoo. I have a few other ideas: (more…)
A patient receiving a flu shot.
In the not too distant future, the phrase “shooting up” could take on a whole new meaning. At least if the U.S. Army has its way. Wired‘s Danger Room blog reported a few days ago that the military is seeking bids for a high-tech form of vaccination that could be delivered quickly and efficiently to a large number of troops in the heat of battle. More specifically, the Pentagon wants a DNA vaccine that can be administered via a literal shot to the arm—and a jolt of electricity. All without causing too much “discomfort” to the patient, of course.
Suffice it to say that this futuristic-sounding vaccine would be a far cry from what you and I received as children. As last year’s swine flu epidemic made painfully clear, our current methods of vaccine development, which have remained essentially unchanged for decades, are woefully outdated. The vaccines take too long—upwards of seven months—to produce, are easily prone to failure if not prepared correctly and, in many cases, lose their potency after only a year. These failings have helped draw attention to DNA-based vaccines, cocktails of genetically engineered plasmids which offer the promise of inducing a stronger, and more targeted, immune response. Where regular vaccines are slow to develop and hard to combine, DNA vaccines can be made relatively quickly and mixed together to ward off multiple pathogens at once. They are also generally safer to produce and administer, more durable and can be scaled more easily.
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