The engineered ovary after 48 hours.
For many cancer patients, treatment can be a double-edged sword. While recent advances in chemotherapy, radiation therapy, and surgery have brought relief to millions of sufferers, a significant fraction have had to sacrifice their ability to have children in return. Going under the knife or being bombarded by high-energy rays—though often critical for therapy—can sometimes irreparably damage a woman’s eggs or man’s testes, robbing them of their fertility. To say that this leaves young patients pondering therapy with an unenviable set of choices would be something of an understatement.
Fortunately, thanks to some groundbreaking work by researchers from Brown University, female patients may soon never have to make this most difficult of decisions. A team led by Sandra Carson, a professor of obstetrics and gynecology, has built the first synthetic human ovary from scratch by cobbling together the three cell lines involved in egg development—the theca cells, granulosa cells, and egg cells themselves—into a fully three-dimensional honeycomb-shaped structure.
Researchers’ new-found interest in frogs may only be skin-deep, but that’s not necessarily a bad thing. Because hidden within their rugose (science-ese for “wrinkled”) flesh may lie a bumper crop of powerful antibiotics. Though hardly a secret among researchers, who’ve been singing their praises as a potential treasure trove for new drugs for years, efforts to systematically catalog—or even investigate—the thousands of amphibians that could yield promising new antimicrobial substances have been few and far between.
Having already become a ubiquitous part of our mobile-centric daily lives, wireless technologies are now poised to slip inside our bodies. Researchers and companies around the world are designing the next generation of biosensors—implantable microchip-like devices that can monitor a patient’s health and ping doctors on their smartphones or computers if something is amiss. One day, some of these devices could even apply short-term fixes or treat disorders outright.
The major challenge that scientists face is developing a sensor that is both long-lived and biocompatible. The human body is extremely picky about implants, and will quickly reject or react poorly to most materials found in everyday electronics. Even the materials that make peace with the body’s immune system, like those found in pacemakers, are not always ideal. Some require constant maintenance, while others need to be replaced every few days and are inconvenient to install, to say the least.