Pluto crosses Neptune's orbit, but due to the timings of their motion they never get very close; Pluto is in no danger of crashing into Neptune. So this picture taken by New Horizons is from a long way off: 4 billion kilometers, in fact! Neptune actually gets closer than this to Earth sometimes... which may give you an idea of just how far away this spacecraft is. The shot shows Neptune (overexposed in the middle) as well as its frozen moon Triton. Pluto and Triton have quite a bit in common -- they're about the same size, temperature, and have the same atmospheric composition -- so this was a good practice shot for the mission. It also gives me a lot of confidence that when it does pass by Pluto, we'll get some amazing pictures.
Related post: Why King Triton, how nice to see you
Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute