Am I A Peer Review Hypocrite?

By Neuroskeptic | August 24, 2015 10:53 am

Am I a hypocrite about peer review?


I was thinking about this today. Here’s why I might be one.

On the one hand, I regularly criticize peer-reviewed research papers for being unsound. I’ve also expressed doubts about the reliability of the peer review process itself. And I do all this on my blog, which is not peer reviewed. So it seems that I don’t respect peer review as a guarantee of scientific truth.

However, I also criticize things for not being peer reviewed. For instance, I roll my eyes at journalists who dare to write about research before it’s been published in a peer reviewed journal.

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CATEGORIZED UNDER: media, papers, science, select, Top Posts

The Myth of Beer Goggles?

By Neuroskeptic | August 20, 2015 6:32 am

A new study casts doubt on the idea that alcohol causes people to seem more attractive – the famous “beer goggles” effect.

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CATEGORIZED UNDER: drugs, papers, select, Top Posts

The Strange World of “Reward Deficiency Syndrome” (Part 3)

By Neuroskeptic | August 17, 2015 4:34 am

In Part 1 of this post I discussed the first issue of a new scientific journal, the Journal of Reward Deficiency Syndrome (JRDS). JRDS is an unusual publication because one man, Kenneth Blum, was involved in editing, publishing, and writing most of the papers in it. In Part 2 I examined the science of “reward deficiency syndrome” (RDS), Blum’s neurobiological theory of addiction.


In this post, I’ll explore another aspect of the RDS story – the business side.

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CATEGORIZED UNDER: drugs, mental health, science, select, Top Posts

The Rise and Fall of Neurotransmitters

By Neuroskeptic | August 15, 2015 5:46 am

There are dozens of neurotransmitters in the human brain. How do neuroscientists decide which transmitters are most important? Are there trends and fashions in neuroscience, such that some transmitters rise and fall in popularity?

I searched PubMed for nine different neurotransmitters, and downloaded the ‘Results by Year’ data to track the number of peer-reviewed papers published each year from 1960 to 2014. The results are very interesting:


Here are some of my observations in no particular order:

The stagnation of serotonin (red): after growing steadily from 1960 to 2005, the number of papers about serotonin has flat-lined. This is possibly a reflection of the stagnation of research into selective serotonin re-uptake inhibitor (SSRI) antidepressants which likewise plateaued around 2005 (although it has started to grow again lately, unlike serotonin). This, in turn, may be related to the fact that most of the SSRI drugs went off-patent around this period. However, this can’t explain why GABA (purple) and endocannabinoids (black) stagnated over the same period. Hmm.

Dopamine (blue) is on the march: it’s the only transmitter that’s been steadily growing research since 1960.

The decline of noradrenaline/norepinephine (green): it was once the hottest transmitter, but something happened in the mid 1980s, and noradrenaline’s research output flat-lined, and then began to shrink. What went wrong? Maybe it was related to…

The rise and fall of substance p (orange) and the endorphins (pale blue): these two neuropeptides were discovered to be neurotransmitters in the late 1970s. Research on them grew rapidly but it didn’t last – by the early 1990s, they had each entered a decline from which they’ve never recovered. At one point the endorphins were more popular than GABA, but by 2014, 28 times more papers were published about GABA than about endorphins.

Note: This post is an update of one of my first ever posts, from 2008.

Are There Too Many Meta-Analyses? (Updated)

By Neuroskeptic | August 10, 2015 3:59 pm

Meta-analyses are systematic syntheses of scientific evidence, most commonly randomized controlled clinical trials. A meta-analysis combines the results of multiple studies and can lead to new insights and more reliable results.

However, according to Italian surgeon Giovanni Tebala writing in Medical Hypotheses, meta-analyses are becoming too popular, and are in danger of taking over the medical literature.

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No Evidence for an Early Dementia Epidemic

By Neuroskeptic | August 7, 2015 9:13 am

Another day, another alarming brain-related story hits the news:

Dementia is striking victims earlier and death rates are soaring

Modern living has led to earlier dementia, says study
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A Close Look at the Connectivity of a Single Brain

By Neuroskeptic | August 2, 2015 8:54 am

In a new paper just out in Neuron, researchers Timothy Laumann and colleagues present an in-depth look at a single human brain.

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CATEGORIZED UNDER: fMRI, papers, science, select, Top Posts

Social Priming: Time for A Definitive Test?

By Neuroskeptic | July 30, 2015 3:02 pm

The scientific controversy over social priming – the (claimed) ability of incidental exposure to stimuli to ‘prime’ or evoke complex behaviors – has been rumbling for the past few years. Will it ever end?

In this post I’ll propose one way in which I think it could be resolved.

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“Right Wing Brain Surgeons” And The NFL

By Neuroskeptic | July 28, 2015 5:07 am

This week (via Retraction Watch) we learned about the case of Joseph Maroon. Earlier this year Maroon and colleagues published a paper arguing that the much-discussed issue of chronic traumatic encephalopathy (CTE) may not be a widespread problem in contact sports such as American football.


However, it turns out that Maroon did not fully declare his conflicts of interest, which include links to the NFL and also World Wrestling Entertainment (WWE).

Maroon, who amongst other things is lead neurosurgeon for the Pittsburgh Steelers football team, issued a Correction acknowledging his interests in this area. The question of which athletes are at risk of CTE has potential legal and financial implications for sports organisations such as NFL and WWE.

Now this story got my attention because Maroon is also linked to Surgical Neurology International (SNI), an academic journal that I blogged about earlier this year: Right-Wing Brain Surgeons.

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“Is Your Brain Really Necessary?”, Revisited

By Neuroskeptic | July 26, 2015 7:40 am

According to British biochemist Donald R. Forsdyke in a new paper in Biological Theory, the existence of people who seem to be missing most of their brain tissue calls into question some of the “cherished assumptions” of neuroscience.

I’m not so sure.

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No brain. No gain.

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